Liver X receptors (LXRs) are regulators of cholesterol metabolism that also modulate
immune responses. Inactivation of LXR α and β in mice leads to autoimmunity; however,
how the regulation of cholesterol metabolism contributes to autoimmunity is unclear. Here
we found that cholesterol loading of CD11c+ cells triggered the development of
autoimmunity, whereas preventing excess lipid accumulation by promoting cholesterol efflux
was therapeutic. LXRβ-deficient mice crossed to the hyperlipidemic ApoE-deficient …